Enzyme markers of collagen synthesis in carbon tetrachloride-induced fibrosis and during colchicine modification of CCl4-induced liver injury.

@article{Bolarin1987EnzymeMO,
  title={Enzyme markers of collagen synthesis in carbon tetrachloride-induced fibrosis and during colchicine modification of CCl4-induced liver injury.},
  author={D. M. Bolarin and K A Barker and George Charles Fuller},
  journal={Experimental and molecular pathology},
  year={1987},
  volume={46 2},
  pages={
          145-52
        }
}
Effects of colchicine and colchiceine in a biochemical model of liver injury and fibrosis.
TLDR
The compound colchiceine may be recommended in the treatment of chronic liver diseases rather than its precursor, colchicine, due to the fact that it showed a lower accumulation of collagen content and has a better anti-fibrogenic effect than does colchicaine.
Human lysyl hydroxylase isoforms : multifunctionality of human LH3 and the amino acids important for its collagen glycosyltransferase activities
TLDR
The sequence alignment of LH isoforms from different species revealed that there are 29 amino acids conserved between human LH3, mouse LH3 and C. elegans LH sequences, showing the importance of this motif for collagen glycosyltransferases and suggesting that it might serve as the Mn2+ binding site in collagen.
Colchicine therapy for hepatic murine schistosomal fibrosis: image analysis and serological study
TLDR
Subsidence of schistosomal infection by praziquantel prior to colchicine therapy greatly reduced inflammatory cellular reaction, significantly diminished hepatic collagen deposition and serum IL‐2 level, and minimized the elevated nuclear ploidy and cyclic AMP serum level that followed colchichine therapy when administered alone.
Effect of colchicine on lactate hepatocytes in rats treated with ethanol production by isolated carbon tetrachloride and
TLDR
The results suggest that colchicine improves the fibrosis by a mechanism independent of hepatic lactate metabolism, and may be important in explaining the beneficial mechanism of this therapy on liver cirrhosis.
Proline interaction with trichloromethyl and trichloromethyl peroxyl free radicals in a model system: studies about the nature of the reaction products formed.
TLDR
The analysis of the reaction products formed by gas chromatography-mass spectrometry of the sylilated derivatives revealed the formation of at least 11 reaction products under anaerobic conditions and 13 under aerobic atmosphere, and all but 2 were proline analogs.
Markers of Laminin and Type I Collagen in Sera of Patients with Sickle Cell Disease
TLDR
Findings indicate that serum markers of type I collagen and laminin may be useful as valuable non-invasive indices of extracellular matrix in bone, spleen or other tissues in sickle cell disease.
The fate of collagen during experimental liver lesion with carbon tetrachloride in the presence and absence of colchicine.
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Assays of serum galactosylhydroxylysyl glucosyltransferase activity and liver galacto-glucosyl transferase activity in liver disease may give useful information on the actual hepatic collagen synthesis, according to the results.
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