Enzyme linked immunosorbent assay (ELISA) for the detection of serum antibodies to the inner core lipopolysaccharide of Neisseria meningitidis group B.

@article{Plested2000EnzymeLI,
  title={Enzyme linked immunosorbent assay (ELISA) for the detection of serum antibodies to the inner core lipopolysaccharide of Neisseria meningitidis group B.},
  author={Joyce S Plested and Margaret Anne J Gidney and Philip A Coull and Hugh Griffiths and Mark A Herbert and A. Graham Bird and James C. Richards and E . Richard Moxon},
  journal={Journal of immunological methods},
  year={2000},
  volume={237 1-2},
  pages={73-84}
}
We have developed a solid-phase ELISA to study the human immune response to inner core lipopolysaccharide (LPS) of Neisseria meningitidis (Nm) using structurally defined glycolipids from a genetically defined mutant (galE) of a serogroup B Nm strain. Previous studies had demonstrated that a galE (inner core) LPS epitope is conserved in approximately 70% Nm strains and was accessible to antibody in fully encapsulated wild-type Nm strains. A murine monoclonal antibody, MAb B5, raised to a galE… CONTINUE READING
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