Enzyme-like acceleration for the hydrolysis of a DNA model promoted by a dinuclear Zn(II) catalyst in dilute aqueous ethanol.

  title={Enzyme-like acceleration for the hydrolysis of a DNA model promoted by a dinuclear Zn(II) catalyst in dilute aqueous ethanol.},
  author={C. Liu and A. A. Neverov and R. Brown},
  journal={Journal of the American Chemical Society},
  volume={130 42},
The rates and products of cleavage of methyl (2-chloro-4-nitrophenyl) phosphate (2) promoted by a dinuclear Zn(II) complex (3) of 1,3-bis-N,N'(1,5,9-triazacyclododecyl)propane along with 1 equiv of ethoxide were investigated in ethanol solution containing small amounts of water (8 mM <or= [H2O] <or= 2.1 M) at 25 degreesC and sspH 7.9. The kinetics of decomposition of 5 x 10(-5) M 2 in the presence of varying [3] (0.03 mM <or= [3] <or= 0.12 mM) in ethanol containing 28 mM water show very strong… Expand
Cleavage of models for RNA mediated by a diZn(II) complex of bis[1,4-N1,N1′(1,5,9-triazacyclododecanyl)]butane in methanol and ethanol
The cleavage of seven RNA model 2-hydroxypropyl aryl phosphates (1) catalyzed by a dinuclear Zn(II) complex of bis[1,4-N1,N1′(1,5,9-triazacyclododecanyl)]butane (4) was studied in methanol andExpand
DFT computational study of the methanolytic cleavage of DNA and RNA phosphodiester models promoted by the dinuclear Zn(II) complex of 1,3-bis(1,5,9-triazacyclododec-1-yl)propane.
A density functional theory study of the cleavage of a DNA model and two RNA models promoted by the dinuclear Zn((II)) complex of 1,3-bis(1,5,9-triazacyclodododec-1-yl)propane formulated with a bridging methoxide was undertaken to determine possible mechanisms for the transesterification processes that are consistent with experimental data. Expand
Steric effects on the catalytic activities of zinc(II) complexes containing [12]aneN3 ligating units in the cleavage of the RNA and DNA model phosphates.
The work has further confirmed that the combination of the cooperativity between two metal ions and a medium effect could result in excellent catalytic activities for the cleavage of phosphate diesters. Expand
Carboxy and diphosphate ester hydrolysis promoted by di- or tri-nuclear zinc(II) complexes based on β-cyclodextrin
Abstract A new ligand (L), 6-mono-(2-(2-hydroxy-3-(hydroxymethyl)-5-methyl benzylamino)-ethylamino)-β-cyclodextrin, based on β-cyclodextrin derivatives with dinucleating units was synthesized andExpand
Dinuclear Zn(II) catalysts as biomimics of RNA and DNA phosphoryl transfer enzymes: changing the medium from water to alcohol provides enzyme‐like rate enhancements
Phosphodiesters are notoriously hydrolytically inert compounds that are demonstrated to have large accelerations of P-OR cleavage promoted by transition and lanthanide metal ions in methanol andExpand
DNA binding, DNA hydrolase and phosphatase like activity of new polyaza macrobicyclic binuclear copper(II), nickel(II) and zinc(II) complexes
Abstract A new class of mono, polyaza macrobicyclic binuclear copper(II), nickel(II) and zinc(II) complexes 1–6 are synthesized and characterized. The redox, phosphate hydrolysis, DNA binding andExpand
Solvolysis mechanisms of RNA phosphodiester analogues promoted by mononuclear zinc(II) complexes: mechanisic determination upon solvent medium and ligand effects.
The theoretical results are consistent with and well interpret the experimental observations and provide practical suggestions on the catalyst design and selection of reaction conditions and the computational results are indicative of concerted pathways. Expand
Synthesis of mono- and di-[12]aneN3 ligands and study on the catalytic cleavage of RNA model 2-hydroxypropyl-p-nitrophenyl phosphate with their metal complexes.
Results clearly indicate that the structures of the linker between two [12]aneN(3) units play very important role in their catalytic synergistic effects. Expand
A series of oxyimine-based macrocyclic dinuclear zinc(II) complexes enhances phosphate ester hydrolysis, DNA binding, DNA hydrolysis, and lactate dehydrogenase inhibition and induces apoptosis.
The results demonstrated that 6, a dizinc(II) complex with potent antiproliferative activity, is able to induce caspase-dependent apoptosis in human cancer cells. Expand
Reactivity of Dinuclear Copper(II) Complexes with N‐Salicylidene Glycine Schiff Bases as Carboxylesterase Models
Two phenoxo-bridged dinuclear copper(II) complexes (Cu2L12, Cu2L22) with N-salicylidene glycine Schiff bases were prepared and evaluated their performance for catalyzing the hydrolysis ofExpand