Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.

@article{Bartling2007EnzymekineticIO,
  title={Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.},
  author={Asja Bartling and Franz Worek and Ladislaus Szinicz and Horst Thiermann},
  journal={Toxicology},
  year={2007},
  volume={233 1-3},
  pages={
          166-72
        }
}
The pertinent threat of using organophosphorus compound (OP)-type chemical warfare agents (nerve agents) during military conflicts and by non-state actors requires the continuous search for more effective medical countermeasures. OP inhibit acetylcholinesterase (AChE) and therefore standard treatment of respective poisoning includes AChE reactivators (oximes) in combination with antimuscarinic agents. Hereby, standard oximes, 2-PAM and obidoxime, are considered to be rather insufficient against… CONTINUE READING
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[Cholinesterase activity assays and their use in the diagnosis of various pathological states including poisoning by neurotoxic agents].

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