Enzyme injection as nonsurgical treatment of Dupuytren's disease.

@article{Badalamente2000EnzymeIA,
  title={Enzyme injection as nonsurgical treatment of Dupuytren's disease.},
  author={M. Badalamente and L. Hurst},
  journal={The Journal of hand surgery},
  year={2000},
  volume={25 4},
  pages={
          629-36
        }
}
Surgical fasciectomy is the currently accepted treatment of Dupuytren's disease. The goal of this study was to test the clinical safety and efficacy of clostridial collagenase injection as a nonsurgical treatment of Dupuytren's disease in a phase II open-label trial. Thirty-five Dupuytren's disease patients entered the study (32 men and 3 women). The mean age was 65 years. The first 6 patients were treated following a dose escalation protocol and received 300, 600, 1,200, 2,400, 4,800, and 9… Expand
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