Enzyme induction with antiepileptic drugs: Cause for concern?

  title={Enzyme induction with antiepileptic drugs: Cause for concern?},
  author={M. Brodie and S. Mintzer and A. Pack and B. Gidal and C. Vecht and D. Schmidt},
  • M. Brodie, S. Mintzer, +3 authors D. Schmidt
  • Published 2013
  • Medicine
  • Epilepsia
  • Several commonly prescribed antiepileptic drugs (AEDs)—including phenobarbital, phenytoin, and carbamazepine—stimulate the synthesis of a broad range of monooxygenase and conjugating enzymes. These agents are well known to reduce the duration and action of many lipid‐ and non–lipid‐soluble drugs, including anticoagulants, cytotoxics, analgesics, antiretrovirals, glucocorticoids, statins, antihypertensives, oral contraceptives, psychoactive drugs, immunosuppressants, and of course, other AEDs… CONTINUE READING
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