Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET).

@article{Das2008EnzymeIA,
  title={Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET).},
  author={Parikshit C. Das and Yan Cao and Randy L. Rose and Nathan J Cherrington and Ernest Hodgson},
  journal={Drug metabolism and drug interactions},
  year={2008},
  volume={23 3-4},
  pages={237-60}
}
Xenobiotics, including drugs and environmental chemicals, can influence cytochrome P450 (CYP) levels by altering the transcription of CYP genes. To minimize potential drug-pesticide and pesticide-pesticide interactions it is important to evaluate the potential of pesticides to induce CYP isoforms and to cause cytotoxicity in humans. The present study was designed to examine chlorpyrifos and DEET mediated induction of CYP isoforms and also to characterize their potential cytotoxic effects on… CONTINUE READING

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