Enzyme-dependent ascorbate recycling in human erythrocytes: role of thioredoxin reductase.

  title={Enzyme-dependent ascorbate recycling in human erythrocytes: role of thioredoxin reductase.},
  author={Seema Mendiratta and Zhenhuan Qu and James Michael May},
  journal={Free radical biology & medicine},
  volume={25 2},
Human erythrocytes efficiently reduce dehydroascorbic acid (DHA) to ascorbate, which helps to maintain the ascorbate content of blood. Whereas erythrocyte DHA reduction is thought to occur primarily through a direct chemical reaction with GSH, this work addresses the role of enzyme-mediated DHA reduction by these cells. The ability of intact erythrocytes to recycle DHA to ascorbate, estimated as DHA-dependent ferricyanide reduction, was decreased in parallel with GSH depletion by glutathione-S… CONTINUE READING


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