Enzyme-catalyzed formation of glycosidic linkages.

  title={Enzyme-catalyzed formation of glycosidic linkages.},
  author={Gregory M Watt and Philip A. S. Lowden and Sabine L Flitsch},
  journal={Current opinion in structural biology},
  volume={7 5},
Significant progress has recently been achieved in the use of glycosidases and glycosyltransferases as synthetic tools. Glycosidases have been used to synthesize trisaccharides with a reasonable overall yield, as well as high-mannose neoglycoconjugates. Studies on glycosyltransferases have defined reaction mechanisms and demonstrated reasonable substrate tolerance of these enzymes. Effective methodology for the synthesis of defined glycoproteins has also been demonstrated. 

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