Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan.

@article{Alonen2008EnzymeassistedSA,
  title={Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan.},
  author={Anna Alonen and Johanna Jansson and Sirkku E Kallonen and Alexandros Kiriazis and Olli Aitio and Moshe Finel and Risto Kostiainen},
  journal={Bioorganic chemistry},
  year={2008},
  volume={36 3},
  pages={148-55}
}
Three angiotensin II receptor antagonists--losartan, candesartan, and zolarsartan--were investigated. All the compounds, which are structural analogues, are metabolized via conjugation to glucuronic acid. Interestingly, both O- and N-glucuronidation take place, so that regioisomers are formed. One ether O-glucuronide, two acyl O-glucuronides, and five tetrazole-N-glucuronides were biosynthesized, in milligram scale, from the three sartan aglycones. Liver microsomes from bovine, moose, rat, and… CONTINUE READING

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