Enzyme allocation problems in kinetic metabolic networks: optimal solutions are elementary flux modes.

@article{Mller2014EnzymeAP,
  title={Enzyme allocation problems in kinetic metabolic networks: optimal solutions are elementary flux modes.},
  author={Stefan M{\"u}ller and Georg Regensburger and Ralf Steuer},
  journal={Journal of theoretical biology},
  year={2014},
  volume={347},
  pages={182-90}
}
The survival and proliferation of cells and organisms require a highly coordinated allocation of cellular resources to ensure the efficient synthesis of cellular components. In particular, the total enzymatic capacity for cellular metabolism is limited by finite resources that are shared between all enzymes, such as cytosolic space, energy expenditure for amino-acid synthesis, or micro-nutrients. While extensive work has been done to study constrained optimization problems based only on… CONTINUE READING
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