Enzyme activity measured in single muscle fibers in partial cytochrome c oxidase deficiency.

@article{Reichmann1988EnzymeAM,
  title={Enzyme activity measured in single muscle fibers in partial cytochrome c oxidase deficiency.},
  author={Heinz Reichmann},
  journal={Neurology},
  year={1988},
  volume={38 2},
  pages={244-9}
}
Single-fiber analyses using a kinetic microphotometric method were performed on three patients with chronic progressive external ophthalmoplegia and proximal myopathy accompanied by a partial deficiency of cytochrome c oxidase. Two patients had subsarcolemmal accumulation of mitochondria (ragged-red fibers). Qualitative histochemical demonstration of cytochrome c oxidase showed a mosaic of fibers without detectable cytochrome c oxidase activity. Quantitative single fiber measurements in the… CONTINUE READING
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