Enzyme activities of tryptophan metabolism along the kynurenine pathway in various species of animals.

@article{Allegri2003EnzymeAO,
  title={Enzyme activities of tryptophan metabolism along the kynurenine pathway in various species of animals.},
  author={Graziella Allegri and Carlo Virgilio Luigi Costa and Antonella Bertazzo and Monica Biasiolo and Eugenio Ragazzi},
  journal={Farmaco},
  year={2003},
  volume={58 9},
  pages={
          829-36
        }
}
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This work presents fluorescent properties of chosen urine fluorophores - i.e. 5-hydroxyindole-3-acetic acid (5-HIAA), indoxyl sulphate (urine indican), serotonin ( 5-HT), vanillylmandelic (VMA) and homovanillic (HVA) acids typical for various diseases.
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References

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Strain differences in the tryptophan metabolite excretion and enzyme activities along the kynurenine pathway in rats.
TLDR
There is a good correlation between urinary excretory values of the metabolites and enzyme activities in the same strain of rats, however, some differences appear when the data are compared among different strains.
Animal liver tryptophan pyrrolases: Absence of apoenzyme and of hormonal induction mechanism from species sensitive to tryptophan toxicity.
TLDR
It is suggested that rat, mouse, pig, turkey, chicken and possibly man are not suitable as models for studying human tryptophan metabolism and the hormonal mechanism of induction of the pyrrolase is absent from species lacking the apoenzyme.
Kynureninase and kynurenine 3-hydroxylase in mammalian tissues.
  • E. Okuno, R. Kido
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    Advances in experimental medicine and biology
  • 1991
The major pathway of tryptophan catabolism in mammals is the kynurenine pathway. L-Tryptophan 2,3-dioxygenase, which is localized in liver and is induced by loading of tryptophan or treatment with
Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma.
TLDR
Kynurenine was the only tryptophan derivative excreted in significantly higher quantities in mice with melanoma with respect to the controls, in agreement with a significantly higher activity of hepatic tryPTophan pyrrolase in micewith melanoma.
Guinea-pig liver tryptophan pyrrolase. Absence of detectable apoenzyme activity and of hormonal induction by cortisol and possible regulation by tryptophan.
TLDR
It is suggested that tryptophan may regulate the activity of guinea-pig liver tryPTophan pyrrolase by mobilizing a latent form of the enzyme whose primary function is the detoxication of its substrate.
EFFECT OF EXPOSURE TO LIGHT ON ENZYME ACTIVITIES and TRYPTOPHAN METABOLITES OF THE KYNURENINE PATHWAY IN WISTAR, IN HETEROZYGOUS and HOMOZYGOUS ADULT and NEWBORN GUNN RATS
TLDR
Male and female Wistar and heterozygous Gunn rats showed a higher activity of tryptophan pyrrolase than the groups of homozygotes in agreement with the data of the metabolites excreted, and Phototherapy did not seem to influence these enzyme activities.
Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme.
The presence of indolylamine 2,3-dioxygenase was examined in human subjects by determining its activity with L-tryptophan as substrate. Enzyme activity was detected in various tissues, and was
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