Enzyme activities along the tryptophan-nicotinic acid pathway in alloxan diabetic rabbits.

  title={Enzyme activities along the tryptophan-nicotinic acid pathway in alloxan diabetic rabbits.},
  author={Eugenio Ragazzi and Carlo Virgilio Luigi Costa and Laura Caparrotta and Monica Biasiolo and Antonella Bertazzo and Graziella Allegri},
  journal={Biochimica et biophysica acta},
  volume={1571 1},
Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits.
In diabetic rabbits, there is an alteration of tryptophan metabolism at the level of 3-hydroxyanthranilic acid --> nicotinic acid step, which has the effect of reducing the biosynthesis of NAD in diabetes.
Tryptophan metabolism in rabbits.
It is suggested that, in rabbit, tryptophan is mainly metabolised along the kynurenine pathway although the apo-TDO enzyme is lacking, as high indole 2,3-dioxygenase activity can obviate this lack.
The kynurenine pathway enzymes in healthy and hyperlipidemic rabbits.
Hyperlipidemia can influence enzyme activities along the kynurenine pathway, leading to a reduction in the biosynthesis of NAD coenzymes.
The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats.
Kynurenine pathway enzymes in different species of animals.
The activity of aminocarboxymuconate-semialdehyde decarboxylase was higher in kidney than in liver only in guinea pig, whereas in rat and mouse, serum tryptophan levels were higher, rat having the highest concentrations.
Recent advances in physiological and pathological significance of tryptophan-NAD+ metabolites: lessons from insulin-producing pancreatic beta-cells.
  • H. Okamoto
  • Biology
    Advances in experimental medicine and biology
  • 2003
It is proposed that maintenance of the NAD+ level is essential for the synthesis and secretion of insulin, and presented a unifying model for beta-cell damage and its prevention (The Okamoto model), in which PARP activation plays an essential role.
Identification of novel molecular candidates for fatty liver in the hyperlipidemic mouse model, HcB19 Published, JLR Papers in Press, April 1, 2004. DOI 10.1194/jlr.M400062-JLR200
Several differential proteins in the hepatic proteome of mice with fatty liver, including PCCA and 3HAAO, are newly identified and confirmed differential expression of previously reported proteins.


Xanthine oxidase activity in human tissues and its inhibition by allopurinol (4-hydroxypyrazolo[3,4-d] pyrimidine).
The xanthine oxidase activity of body fluids and tissues which are accessible to biopsy in the living human subject, and of some human necropsy tissues, have been determined.
Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms.
1. The administration of haematin or 5-aminolaevulinate to rat enhances the activity of liver tryptophan pyrrolase; both endogenous and newly formed apoenzymes become strongly haem-saturated. Haem
Animal liver tryptophan pyrrolases: Absence of apoenzyme and of hormonal induction mechanism from species sensitive to tryptophan toxicity.
It is suggested that rat, mouse, pig, turkey, chicken and possibly man are not suitable as models for studying human tryptophan metabolism and the hormonal mechanism of induction of the pyrrolase is absent from species lacking the apoenzyme.
Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate.