Enzyme-Transporter Interplay in the Formation and Clearance of Abundant Metabolites of Faldaprevir Found in Excreta but not in Circulation s

@inproceedings{Li2014EnzymeTransporterII,
  title={Enzyme-Transporter Interplay in the Formation and Clearance of Abundant Metabolites of Faldaprevir Found in Excreta but not in Circulation s},
  author={Yongmei Li and Jin Zhou and Diane Ramsden and Mitchell E. Taub and O Dran{\'e} and Brien and Jun Xu and Carl A. Busacca and Nina C Gonnella and Donald J. Tweedie},
  year={2014}
}
Faldaprevir is a hepatitis C virus protease inhibitor that effectively reduces viral load in patients. Since faldaprevir exhibits slow metabolism in vitro and low clearance in vivo, metabolism was expected to be a minor clearance pathway. The human [C] absorption, distribution, metabolism, and excretion study revealed that two monohydroxylated metabolites… CONTINUE READING