Enzyme Replacement with Recombinant β-Glucuronidase in the Newborn Mucopolysaccharidosis Type VII Mouse

@article{Vogler1993EnzymeRW,
  title={Enzyme Replacement with Recombinant β-Glucuronidase in the Newborn Mucopolysaccharidosis Type VII Mouse},
  author={Carole Vogler and Mark S Sands and Ann Higgins and Beth Levy and Jeffery Grubb and Edward H. Birkenmeier and William S. Sly},
  journal={Pediatric Research},
  year={1993},
  volume={34},
  pages={837-840}
}
ABSTRACT: β-Glucuronidase injected i.v. into newborn mucopolysaccharidosis VII mice was cleared from the circulation in less than 1 h and taken up by tissues in a distribution corresponding to the location of the mannose 6-phosphate receptor. One h after a 3.5-mg/kg β-glucuronidase injection, β-glucuronidase levels were equal to or greater than normal in every organ examined with the exception of the brain, where 31% normal activity was present. Enzyme was detectable histochemically in the… CONTINUE READING

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The half - life of recombinant β-glucuronidase activity in various organs of injected mucopolysaccharidosis VII mice was 1.5 to 4.5 d. These studies show that recombinant β-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII .
The half - life of recombinant β-glucuronidase activity in various organs of injected mucopolysaccharidosis VII mice was 1.5 to 4.5 d. These studies show that recombinant β-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII .
The half - life of recombinant β-glucuronidase activity in various organs of injected mucopolysaccharidosis VII mice was 1.5 to 4.5 d. These studies show that recombinant β-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII .
The half - life of recombinant β-glucuronidase activity in various organs of injected mucopolysaccharidosis VII mice was 1.5 to 4.5 d. These studies show that recombinant β-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII .
The half - life of recombinant β-glucuronidase activity in various organs of injected mucopolysaccharidosis VII mice was 1.5 to 4.5 d. These studies show that recombinant β-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII .
The half - life of recombinant β-glucuronidase activity in various organs of injected mucopolysaccharidosis VII mice was 1.5 to 4.5 d. These studies show that recombinant β-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII .
The half - life of recombinant β-glucuronidase activity in various organs of injected mucopolysaccharidosis VII mice was 1.5 to 4.5 d. These studies show that recombinant β-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII .
The half - life of recombinant β-glucuronidase activity in various organs of injected mucopolysaccharidosis VII mice was 1.5 to 4.5 d. These studies show that recombinant β-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII .
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