Enzyme Polymorphism in Warfarin Dose Management After Pediatric Cardiac Surgery

Abstract

BACKGROUND Warfarin is an anticoagulant and is widely used for the prevention of thromboembolic events. Genetic variants of the enzymes that metabolize warfarin, i.e. cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1), contribute to differences in patients' responses to various warfarin doses. There is, however, a dearth of data on the… (More)
DOI: 10.5812/cardiovascmed.27963v2

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