Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways

@article{Albada2007EnzymeLC,
  title={Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways},
  author={Siebe B van Albada and Pieter Rein ten Wolde},
  journal={PLoS Computational Biology},
  year={2007},
  volume={3},
  pages={85 - 88}
}
Push-pull networks are ubiquitous in signal transduction pathways in both prokaryotic and eukaryotic cells. They allow cells to strongly amplify signals via the mechanism of zero-order ultrasensitivity. In a push-pull network, two antagonistic enzymes control the activity of a protein by covalent modification. These enzymes are often uniformly distributed in the cytoplasm. They can, however, also be colocalized in space; for instance, near the pole of the cell. Moreover, it is increasingly… CONTINUE READING

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