Enzyme-Free Nucleic Acid Logic Circuits

@article{Seelig2006EnzymeFreeNA,
  title={Enzyme-Free Nucleic Acid Logic Circuits},
  author={Georg Seelig and David Soloveichik and David Yu Zhang and Erik Winfree},
  journal={Science},
  year={2006},
  volume={314},
  pages={1585 - 1588}
}
Biological organisms perform complex information processing and control tasks using sophisticated biochemical circuits, yet the engineering of such circuits remains ineffective compared with that of electronic circuits. To systematically create complex yet reliable circuits, electrical engineers use digital logic, wherein gates and subcircuits are composed modularly and signal restoration prevents signal degradation. We report the design and experimental implementation of DNA-based digital… 

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