Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination

Abstract

We recently demonstrated that variants of cytochrome P450BM3 (CYP102A1) catalyze the insertion of nitrogen species into benzylic C-H bonds to form new C-N bonds. An outstanding challenge in the field of C-H amination is catalyst-controlled regioselectivity. Here, we report two engineered variants of P450BM3 that provide divergent regioselectivity for C-H… (More)
DOI: 10.1021/ja509308v

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