Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase.

@article{Li1997EnzymeprodrugGT,
  title={Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase.},
  author={Zhuqing Li and Narkunaraja Shanmugam and Dai Katayose and Bettina Huber and Sundaresha S. Nidhi Srivastava and Kathleen Cowan and Prem Kumar Seth},
  journal={Cancer gene therapy},
  year={1997},
  volume={4 2},
  pages={
          113-7
        }
}
A recombinant adenovirus expressing Escherichia coli cytosine deaminase (AdCD) was constructed with the purpose of exploring its utility for the treatment of breast cancer. Infection of the human breast cancer cell line, MDA-MB-231, with AdCD resulted in high levels of cytosine deaminase enzyme activity. MDA-MB-231 cells infected with AdCD were 1000-fold more sensitive to 5-fluorocytosine (5-FC) than cells infected with a control adenovirus. Cell mixing experiments indicated that only 10% of… CONTINUE READING

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