Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran-hyaluronic acid conjugates for cartilage tissue engineering.

@article{Jin2010EnzymaticallycrosslinkedIH,
  title={Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran-hyaluronic acid conjugates for cartilage tissue engineering.},
  author={R Jin and Liliana Moreira Teixeira and Pieter J. Dijkstra and Clemens A van Blitterswijk and Marcel Karperien and Jan Feijen},
  journal={Biomaterials},
  year={2010},
  volume={31 11},
  pages={
          3103-13
        }
}
Polysaccharide hybrids consisting of hyaluronic acid (HA) grafted with a dextran-tyramine conjugate (Dex-TA) were synthesized and investigated as injectable biomimetic hydrogels for cartilage tissue engineering. The design of these hybrids (denoted as HA-g-Dex-TA) is based on the molecular structure of proteoglycans present in the extracellular matrix of native cartilage. Hydrogels of HA-g-Dex-TA were rapidly formed within 2 min via enzymatic crosslinking of the tyramine residues in the… CONTINUE READING

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