Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering.

@article{Jin2010EnzymaticallyCD,
  title={Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering.},
  author={Rong Jin and Liliana S. Moreira Teixeira and Pieter J. Dijkstra and Zhiyuan Zhong and Clemens A van Blitterswijk and Marcel Karperien and Jan Feijen},
  journal={Tissue engineering. Part A},
  year={2010},
  volume={16 8},
  pages={2429-40}
}
Enzymatic crosslinking of dextran-tyramine (Dex-TA) conjugates in the presence of horseradish peroxidase and hydrogen peroxide was successively applied in the preparation of hydrogels. Depending on the molecular weight of the dextran (M(n,) (GPC) of 14000 or 31000 g/mol) and the degree of substitution (of 5, 10, or 15) with TA groups, the gelation times ranged from 20 s to 1 min. Hydrogels prepared from Dex31k-TA with a degree of substitution of 10 had storage moduli up to 60 kPa. Similar… CONTINUE READING

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