Enzymatically catalyzed HES conjugation using microbial transglutaminase: Proof of feasibility.

@article{Besheer2009EnzymaticallyCH,
  title={Enzymatically catalyzed HES conjugation using microbial transglutaminase: Proof of feasibility.},
  author={A. H. Besheer and Thomas C. Hertel and J{\"o}rg Kressler and Karsten M{\"a}der and Markus Pietzsch},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 11},
  pages={
          4420-8
        }
}
Polymer-drug and polymer-protein conjugates are promising candidates for the delivery of therapeutic agents. PEGylation, using poly(ethylene glycol) for the conjugation, is now the gold standard in this field, and some PEGylated proteins have successfully reached the market. Hydroxyethyl starch (HES) is a water-soluble, biodegradable derivative of starch that is currently being investigated as a substitute for PEG. So far, only chemical methods have been suggested for HES conjugation; however… CONTINUE READING

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