Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis.

@article{Wuest2011EnzymaticTA,
  title={Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis.},
  author={William M. Wuest and Daniel Krahn and Markus Kaiser and Christopher T Walsh},
  journal={Organic letters},
  year={2011},
  volume={13 17},
  pages={4518-21}
}
The enzymatic activation of 3,4-dehydrolysine and subsequent formation of the 12-membered syringolin macrolactam were investigated. The timing of the desaturation was elucidated through the analysis of the initial adenylation domain of SylD. The SylD-TTE didomain was characterized and demonstrated to be the catalyst for formation of 12-membered macrocycles… CONTINUE READING