Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.

Abstract

Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates inordinately high interstitial fluid pressures (IFPs), exceeding those previously measured or theorized for solid tumors, and induces vascular collapse, while presenting substantial barriers to perfusion… (More)
DOI: 10.1016/j.ccr.2012.01.007

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Cite this paper

@article{Provenzano2012EnzymaticTO, title={Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.}, author={Paolo P Provenzano and Carlos Cuevas and Amy Chang and Vikas Goel and Daniel D. Von Hoff and Sunil Hingorani}, journal={Cancer cell}, year={2012}, volume={21 3}, pages={418-29} }