Enzymatic synthesis of chiral intermediates for pharmaceuticals

Abstract

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and β3-receptor receptor agonists are described.

DOI: 10.1007/s10295-003-0032-6

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@article{Patel2003EnzymaticSO, title={Enzymatic synthesis of chiral intermediates for pharmaceuticals}, author={Ramesh Patel and Ronald Hanson and Animesh Goswami and Venkata Nanduri and Amit Banerjee and Mary-Jo Donovan and Steven Goldberg and Robert Johnston and David Brzozowski and Thomas Tully and Jeffrey Howell and Dana Cazzulino and Rapheal Ko}, journal={Journal of Industrial Microbiology and Biotechnology}, year={2003}, volume={30}, pages={252-259} }