Enzymatic synthesis of 2'-deoxypseudouridylic acid.

@article{Kalman1972EnzymaticSO,
  title={Enzymatic synthesis of 2'-deoxypseudouridylic acid.},
  author={Thomas I. Kalman},
  journal={Biochemical and biophysical research communications},
  year={1972},
  volume={46 3},
  pages={
          1194-200
        }
}
  • T. Kalman
  • Published 16 February 1972
  • Biology
  • Biochemical and biophysical research communications
7 Citations
Methylation of 4-thio-2'-deoxyuridylate by thymidylate synthetase.
Nucleosides. CIX. 2′-Deoxy-ψ-isocytidine, 2 -deoxy-ψ-uridine, and 2′-deoxy-l-methyl-ψ-uridine. Isosteres of deoxycytidine, deoxyuridine and thymidine
2′-Deoxy-ψ-isocytidine (VIIβ), a 2′-deoxy analog of antileukemic ψ-isocytidine and also a C-nucleoside analog of deoxycytidine, was synthesized from ψ-uridine by making use of the newly discovered
Rational Design of Pyrimidine Nucleoside Analogs
TLDR
The chemotherapeutic approach to oncology has been rather empirical with the major successes being noted with drugs which are generally more toxic to rapidly proliferating cells.

References

SHOWING 1-7 OF 7 REFERENCES
On the biosynthesis of pseudouridine and of pseudouridylic acid in Agrobacterium tumefaciens.
TLDR
The data presented in this paper permit the first description of the biosynthetic pathway for pseudouridylic acid and for Pseudouridine in a bacterium.
The biochemistry of pseudouridine.
Ribonucleic acids from yeast which contain a fifth nucleotide.
Conformation of pseudouridine and pseudouridine 5'-phosphate. Ultraviolet and nuclear magnetic resonance study.
TLDR
It is concluded, that the presence of a 5'-hydroxyl is without influence on the ultraviolet spectrum and distribution of tautomeric monoanions in pseudouridine.
The chemistry of pseudouridine.
  • R. Chambers
  • Chemistry, Biology
    Progress in nucleic acid research and molecular biology
  • 1966