Enzymatic sulfation of quercetin by arylsulfotransferase from a human intestinal bacterium.

@article{Koizumi1990EnzymaticSO,
  title={Enzymatic sulfation of quercetin by arylsulfotransferase from a human intestinal bacterium.},
  author={Makoto Koizumi and Mikio Shimizu and Kyoichi Kobashi},
  journal={Chemical & pharmaceutical bulletin},
  year={1990},
  volume={38 3},
  pages={
          794-6
        }
}
A novel type of arylsulfotransferase was partially purified from human intestinal bacteria and its enzymatic properties were examined. Polyphenols such as chalcone, xanthone and flavonoid were found to be sulfated by the bacterial arylsulfotransferase though the sulfation activity varied depending upon the positions of the hydroxyl groups. Quercetin, as an example of a flavonol, was rapidly sulfated when p-nitrophenyl sulfate (PNS) was taken as a donor substrate. At a ten-fold molar excess of… CONTINUE READING