Enzymatic resolution of racemic phenyloxirane by a novel epoxide hydrolase from Aspergillus niger SQ-6 and its fed-batch fermentation

@article{Liu2005EnzymaticRO,
  title={Enzymatic resolution of racemic phenyloxirane by a novel epoxide hydrolase from Aspergillus niger SQ-6 and its fed-batch fermentation},
  author={Yanbin Liu and Qian Sha and Sheng Gan Wu and Jianjun Wang and Liu Yang and Wanru Sun},
  journal={Journal of Industrial Microbiology and Biotechnology},
  year={2005},
  volume={33},
  pages={274-282}
}
A microorganism with the ability to catalyze the resolution of racemic phenyloxirane was isolated and identified as Aspergillus niger SQ-6. Chiral capillary electrophoresis was successfully applied to separate both phenyloxirane and phenylethanediol. The epoxide hydrolase (EH) involved in this resolution process was (R)-stereospecific and constitutively expressed. When whole cells were used during the biotransformation process, the optimum temperature and pH for stereospecific vicinal diol… CONTINUE READING

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