Enzymatic resolution of 1-phenyl-1,2-ethanediol by enantioselective oxidation: overcoming product inhibition by continuous extraction.

@article{Liese1996EnzymaticRO,
  title={Enzymatic resolution of 1-phenyl-1,2-ethanediol by enantioselective oxidation: overcoming product inhibition by continuous extraction.},
  author={Andreas Liese and Martin Karutz and J. William Kamphuis and Christian Wandrey and Udo Kragl},
  journal={Biotechnology and bioengineering},
  year={1996},
  volume={51 5},
  pages={
          544-50
        }
}
Oxidations of alcohols by alcohol dehydrogenases often suffer from low conversions and slow reaction rates due to severe product inhibition. This can be overcome by continuous product extraction, because only the concentrations, but not the kinetic parameters, can be changed. As a consequence, it is favorable to apply a differential circulation reactor with continuous product extraction, where only a small amount of product is formed per cycle. The product is then directly extracted using a… CONTINUE READING
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