Enzymatic resolution of (S)-(+)-naproxen in a continuous reactor.

  title={Enzymatic resolution of (S)-(+)-naproxen in a continuous reactor.},
  author={E Battistel and Daniele Bianchi and P Cesti and C. Pina},
  journal={Biotechnology and bioengineering},
  volume={38 6},
An enzymatic method for the continuous production of (S)-(+)-2-(6-methoxy-2-naphthyl) propionic acid (Naproxen) has been developed. The process consists of a stereoselective hydrolysis of the racemic Naproxen ethoxyethyl ester catalyzed by Candida cylindracea lipase. The reaction has been carried out in a continuous-flow closed-loop column bioreactor packed… CONTINUE READING