Enzymatic resistance to the lipopeptide surfactin as identified through imaging mass spectrometry of bacterial competition.

@article{Hfler2012EnzymaticRT,
  title={Enzymatic resistance to the lipopeptide surfactin as identified through imaging mass spectrometry of bacterial competition.},
  author={Benjamin H{\"o}fler and Karl V. Gorzelnik and Jane Y. X. Yang and Nathan G. Hendricks and Pieter C. Dorrestein and Paul D Straight},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 32},
  pages={
          13082-7
        }
}
Many species of bacteria secrete natural products that inhibit the growth or development of competing species. In turn, competitors may develop or acquire resistance to antagonistic molecules. Few studies have investigated the interplay of these countervailing forces in direct competition between two species. We have used an imaging mass spectrometry (IMS) approach to track metabolites exchanged between Bacillus subtilis and Streptomyces sp. Mg1 cultured together. Surfactin is a cyclic… CONTINUE READING

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