Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.

@article{Sanderson2005EnzymaticRO,
  title={Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.},
  author={Ralph D. Sanderson and Yang Yang and Thomas Kelly and Veronica Macleod and Yuemeng Dai and Allison M. Theus},
  journal={Journal of cellular biochemistry},
  year={2005},
  volume={96 5},
  pages={897-905}
}
Heparan sulfate proteoglycans (HSPGs), via their interactions with numerous effector molecules such as FGF-2, IL-8, and VEGF, regulate the biological activity of cells by acting as co-receptors that promote signaling. The extent and nature of their role as co-receptors is often misregulated in cancer as manifested by alterations in HSPG structure and expression level. This misregulation of HSPGs can aid in promoting the malignant phenotype. In addition to expression-related changes in HSPGs… CONTINUE READING

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