Enzymatic reduction studies of nitroheterocycles.

@article{Viod1999EnzymaticRS,
  title={Enzymatic reduction studies of nitroheterocycles.},
  author={C{\'e}cile Viod{\'e} and Nabila Bettache and Narimantas {\vC}ėnas and R. Luise Krauth-Siegel and G{\'e}rard Chauvi{\`e}re and Norbert Bakalara and Jacques P{\'e}ri{\'e}},
  journal={Biochemical pharmacology},
  year={1999},
  volume={57 5},
  pages={
          549-57
        }
}
The nitroimidazole derivative Megazol is a highly active compound used against several strains of Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanomiasis). With the aim of gaining an insight into the probable mode of action, the interaction of Megazol with different redox enzymes was studied in comparison to that of Nifurtimox and Metronidazole. The three nitroaromatic compounds are reduced by L-lactate cytochrome c-reductase, adrenodoxin reductase, and NADPH… CONTINUE READING

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Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?

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