Enzymatic properties of the N- and C-terminal halves of human hexokinase II.

@article{Ahn2009EnzymaticPO,
  title={Enzymatic properties of the N- and C-terminal halves of human hexokinase II.},
  author={Keun Jae Ahn and Jongsun Kim and Mijin Yun and Jeon Han Park and Jong Doo Lee},
  journal={BMB reports},
  year={2009},
  volume={42 6},
  pages={
          350-5
        }
}
Although previous studies on hexokinase (HK) II indicate both the N- and C-terminal halves are catalytically active, we show in this study the N-terminal half is significantly more catalytic than the C-terminal half in addition to having a significantly higher Km for ATP and Glu. Furthermore, truncated forms of intact HK II lacking its first N-terminal 18 amino acids (delta18) and a truncated N-terminal half lacking its first 18 amino acids (delta18N) have higher catalytic activity than other… CONTINUE READING

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