Enzymatic oxidative activation and transformation of the antitumor agent mitoxantrone.

@article{Kolodziejczyk1988EnzymaticOA,
  title={Enzymatic oxidative activation and transformation of the antitumor agent mitoxantrone.},
  author={Paul Kolodziejczyk and Katarzyna Reszka and J. William Lown},
  journal={Free radical biology & medicine},
  year={1988},
  volume={5 1},
  pages={13-25}
}
Ambient temperature incubation of the anticancer agent mitoxantrone with horseradish peroxidase and hydrogen peroxide converts it into a hexahydronaphtho[2,3-f]quinoxaline-7,12-dione in which one side chain has cyclized to the chromophore. The structure of this cyclic metabolite was secured by independent synthesis. This peroxidative conversion of mitoxantrone, the progress of which can be followed spectrophotometrically, is accompanied by formation of a free radical species. The EPR… CONTINUE READING

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