Enzymatic oxidation of the dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion.

@article{Naoi1995EnzymaticOO,
  title={Enzymatic oxidation of the dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion.},
  author={Makato Naoi and Wakkako Maruyama and John H Zhang and Tsutomu Takahashi and Y. Deng and Philippe Dostert},
  journal={Life sciences},
  year={1995},
  volume={57 11},
  pages={1061-6}
}
The dopamine-derived alkaloid, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [N-methyl(R)salsolinol] was found to be oxidized enzymatically into the more cytotoxic species, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, using enzyme sample prepared from human brain cortex. The values of the Michaelis constant and of the maximum velocity were 912 microM and 1,368 pmol/min/mg protein, respectively. The enzyme was not inhibited by inhibitors of monoamine oxidase, but was… CONTINUE READING