Enzymatic oxidation and reduction of C19-delta5-3beta-hydroxysteroids by hepatic microsomes. V. Testosterone as a neonatal determinant in rats of the 7- and 16alpha-hydroxylation and reduction of 3beta-hydroxyandrost-5-en-17-one (DHA).

Abstract

The oxido-reductive metabolism of [14C]dehydroepiandrosterone (DHA) by hepatic microsomes from 40- or 70-day-old rats of either sex castrated neonatally has been compared after several treatment regimens with testosterone propionate (TP). The low transformation rate of DHA to 16-oxygenated metabolites produced by neonatal orchiectomy (0.09 +/- 0.04 nmoles… (More)

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@article{Tabei1975EnzymaticOA, title={Enzymatic oxidation and reduction of C19-delta5-3beta-hydroxysteroids by hepatic microsomes. V. Testosterone as a neonatal determinant in rats of the 7- and 16alpha-hydroxylation and reduction of 3beta-hydroxyandrost-5-en-17-one (DHA).}, author={Tadashi Tabei and Wolfgang Heinrichs}, journal={Endocrinology}, year={1975}, volume={97 2}, pages={418-24} }