Enzymatic modification of self-assembled peptide structures with tissue transglutaminase.

  title={Enzymatic modification of self-assembled peptide structures with tissue transglutaminase.},
  author={Joel H. Collier and Phillip B Messersmith},
  journal={Bioconjugate chemistry},
  volume={14 4},
A de novo peptide that self-assembles into fibrillar structures and serves as a substrate for the cross-linking enzyme tissue transglutaminase was developed (Ac-QQKFQFQFEQQ-Am). Congo red staining, circular dichroism, and FTIR spectroscopy showed that this 11-amino acid peptide produced predominantly beta-sheet structures. TEM with negative staining and quick-freeze deep etch (QFDE) TEM showed that the peptide structures were composed of a highly entangled fibrillar network. These beta-sheet… CONTINUE READING


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