Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.

@article{Gantt2011EnzymaticMF,
  title={Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.},
  author={Richard W. Gantt and Pauline Peltier-Pain and Jon S Thorson},
  journal={Natural product reports},
  year={2011},
  volume={28 11},
  pages={1811-53}
}
Glyco (randomization/diversification) is a term that encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to provide sets of analogs wherein the sole diversity element is a carbohydrate. This review covers the influence of glycosylation upon various drug properties, the classes of glycosyl-conjugating enzymes amenable to… CONTINUE READING