Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.

@article{Hill1972EnzymaticMO,
  title={Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.},
  author={Donald L. Hill and W. Russell Laster and Robert F. Struck},
  journal={Cancer research},
  year={1972},
  volume={32 4},
  pages={658-65}
}
Cyclophosphamide is converted by enzymes of mouse liver into two metabolites. Production of the first (aldophosphamide), which is uncharged, requires TPNH, is inhibited by CO, and is accomplished predominantly by the microsomal fraction. With the microsomal enzyme, the Km for Cyclophosphamide is 0.5 mM; nicotine, atropine, ephedrine, apomorphine, and cocaine are potent inhibitors. Phénobarbital, cytochrome c, 2-diethylaminoethy 1-2,2diphenylvalerate, and some steroid hormones also inhibit the… CONTINUE READING
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