Enzymatic markers of heart lesion in mice infected with Trypanosoma cruzi and submitted to benznidazole chemotherapy

@article{Souza2000EnzymaticMO,
  title={Enzymatic markers of heart lesion in mice infected with Trypanosoma cruzi and submitted to benznidazole chemotherapy},
  author={Andrea Souza and Bianca Perdig{\~a}o Olivieri and Solange Lisboa de Castro and Tania Cremonini de Ara{\'u}jo-Jorge},
  journal={Parasitology Research},
  year={2000},
  volume={86},
  pages={800-808}
}
Creatine kinase (CK total and CK-MB) were studied as markers of lesion progression induced by Trypanosoma cruzi infection. After 3 weeks mice infected with 104 parasites showed an increase in both enzyme levels and in their frequency distribution. A trend to increase was already detected in the 2nd week. A short duration per os treatment with benznidazole (Bz) prevented the occurrence of tissue lesions, since no changes were observed in enzymes. However, in the 4th week, about 40% of Bz-treated… CONTINUE READING

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