Enzymatic glucose sensors. Improved long-term performance in vitro and in vivo.

@article{Updike1994EnzymaticGS,
  title={Enzymatic glucose sensors. Improved long-term performance in vitro and in vivo.},
  author={S J Updike and M C Shults and R K Rhodes and Bruce Gilligan and J O Luebow and Dennis von Heimburg},
  journal={ASAIO journal},
  year={1994},
  volume={40 2},
  pages={157-63}
}
We studied the long-term in vitro and in vivo performance of enzyme electrode glucose sensors. Single commercially produced enzyme-active membranes remained functional for estimating glucose in vitro for 14-36 months. These membranes were implanted subcutaneously in rats for 1 year and, upon explanation, remained functional for measuring glucose in vitro. Sensors with these membranes plus an additional outer membrane with lower glucose permeability allowed glucose monitoring in the low oxygen… CONTINUE READING

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