Enzymatic formation of 9-cis, 13-cis, and all-trans retinals from isomers of beta-carotene.

@article{Nagao1994EnzymaticFO,
  title={Enzymatic formation of 9-cis, 13-cis, and all-trans retinals from isomers of beta-carotene.},
  author={Akihiko Nagao and James A. Olson},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1994},
  volume={8 12},
  pages={
          968-73
        }
}
9-cis Retinoic acid is a highly preferred ligand for the nuclear retinoic acid receptor RXR. Although 9-cis retinoic acid can be formed from all-trans retinoic acid in vivo and in vitro, the nature of the isomerization process has not been defined. 9-cis-Retinoic acid might also be formed biologically from 9-cis beta-carotene, an isomer of beta-carotene commonly found in foods. We have observed that enzyme preparations of rat liver and intestine convert highly purified 9-cis beta-carotene (99.8… CONTINUE READING
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