Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides

@article{Lapolla2004EnzymaticDA,
  title={Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides},
  author={Annunziata Lapolla and Domenico Fedele and Rachele Reitano and Nadia Concetta Aric{\`o} and Roberta Seraglia and Pietro Traldi and Ester Marotta and Roberto Tonani},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2004},
  volume={15},
  pages={496-509}
}
An extensive study was carried out on HSA and non-enzymatically glycated HSA by enzymatic digestion with trypsin and endoproteinase Lys-C, with the aim of identifying specific glycated peptides deriving from enzymatic digestion of glycated HSA. They may be considered, in pectore, as advanced glycation end products/peptides. These compounds, important at a systemic level in diabetic and nephropathic subjects, are produced by enzymatic digestion of in vivo glycated proteins: They are related to… CONTINUE READING
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