Enzymatic defluorination and metabolism of fluoroacetate, fluoroacetamide, fluoroethanol, and (-)-erythro-fluorocitrate in rats and mice examined by 19F and 13C NMR.

@article{Tecle1989EnzymaticDA,
  title={Enzymatic defluorination and metabolism of fluoroacetate, fluoroacetamide, fluoroethanol, and (-)-erythro-fluorocitrate in rats and mice examined by 19F and 13C NMR.},
  author={Berhane Tecle and John E Casida},
  journal={Chemical research in toxicology},
  year={1989},
  volume={2 6},
  pages={
          429-35
        }
}
  • B. Tecle, J. Casida
  • Published 1 November 1989
  • Biology, Chemistry
  • Chemical research in toxicology
Fluoroacetate administered intraperitoneally (ip) to rats and mice is defluorinated to give fluoride ion evident in urine and kidney by 19F NMR. The use of [2-13C]-, [1,2-13C]-, and [1,2-14C]fluoroacetate, prepared from isotopically labeled glycine, combined with 13C NMR and TLC radioautography, respectively, reveals a complex mixture of urinary metabolites including an S-(carboxymethyl) conjugate complex in rats and mice and sulfoxidation products thereof in rats. Direct 13C NMR examination of… 
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