Enzymatic conversion of the antibiotic metronidazole to an analog of thiamine.

@article{Alston1987EnzymaticCO,
  title={Enzymatic conversion of the antibiotic metronidazole to an analog of thiamine.},
  author={T A Alston and Robert H. Abeles},
  journal={Archives of biochemistry and biophysics},
  year={1987},
  volume={257 2},
  pages={357-62}
}
We propose that adverse effects of the antibiotic metronidazole may be due, wholly or in part, to its conversion to a thiamine analog and consequent vitamin B1 antagonism. Consistent with this hypothesis, the drug is accepted as a substrate for the thiaminase (EC 2.5.1.2) elaborated as an exoenzyme by the human gut flora constituent Bacillus thiaminolyticus and is also a substrate for the intracellular thiaminase of the mollusk Venus mercenaria. The product, identified as the 1-[(4-amino-2… CONTINUE READING