Enzymatic conversion of averufin to hydroxyversicolorone and elucidation of a novel metabolic grid involved in aflatoxin biosynthesis.

@article{Yabe2003EnzymaticCO,
  title={Enzymatic conversion of averufin to hydroxyversicolorone and elucidation of a novel metabolic grid involved in aflatoxin biosynthesis.},
  author={K. Yabe and Naomi Chihaya and Shioka Hamamatsu and Emi Sakuno and Takashi Hamasaki and Hiromitsu Nakajima and Joan Wennstrom Bennett},
  journal={Applied and environmental microbiology},
  year={2003},
  volume={69 1},
  pages={
          66-73
        }
}
The pathway from averufin (AVR) to versiconal hemiacetal acetate (VHA) in aflatoxin biosynthesis was investigated by using cell-free enzyme systems prepared from Aspergillus parasiticus. When (1'S,5'S)-AVR was incubated with a cell extract of this fungus in the presence of NADPH, versicolorin A and versicolorin B (VB), as well as other aflatoxin pathway intermediates, were formed. When the same substrate was incubated with the microsome fraction and NADPH, hydroxyversicolorone (HVN) and VHA… CONTINUE READING

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