Enzymatic cleavage of RNA by RNA

@article{Altman1990EnzymaticCO,
  title={Enzymatic cleavage of RNA by RNA},
  author={Sidney Altman},
  journal={Bioscience Reports},
  year={1990},
  volume={10},
  pages={317-337}
}
  • S. Altman
  • Published 1990
  • Chemistry
  • Bioscience Reports
The discovery and characterization of the catalytic RNA subunit of the enzyme ribonuclease P ofEscherichia coli is described. 
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The different possibilities towards progression of the formation of DNA/RNA in the chemical world, before life, in enzyme-free conditions are reviewed and a possible explanation for the specific 3'-5'-linkages in RNA is proposed. Expand
Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA.
RNase MRP is a eukaryote-specific endoribonuclease that generates RNA primers for mitochondrial DNA replication and processes precursor rRNA. RNase P is a ubiquitous endoribonuclease that cleavesExpand
Single Mutation in Hammerhead Ribozyme Favors Cleavage Activity with Manganese over Magnesium
TLDR
A naturally occurring variation in the catalytic core of hammerhead ribozymes, A6C, that can favor one metallic ion, Mn2+, over several other cations is shown. Expand
The post-transcriptional steps of eukaryotic ribosome biogenesis
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Quality control mechanisms are being discovered that monitor ribosome synthesis and degrade the RNA components of defective pre-ribosomal particles. Expand
Programmable design of functional ribonucleoprotein complexes.
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The results indicate that Pumilio and guide RNAs are suitable building blocks for the correct self-assembly of RNP complexes consisting of up to six different components. Expand
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