Enzymatic cleavage of RNA by RNA

@article{Altman1986EnzymaticCO,
  title={Enzymatic cleavage of RNA by RNA},
  author={Sidney Altman},
  journal={Bioscience Reports},
  year={1986},
  volume={10},
  pages={317-337}
}
  • S. Altman
  • Published 1 December 1986
  • Biology
  • Bioscience Reports
The discovery and characterization of the catalytic RNA subunit of the enzyme ribonuclease P ofEscherichia coli is described. 

Distal to Proximal—Functional Coupling in RNase P RNA-mediated Catalysis

TLDR
Bacterial RNase P contains one RNA (RPR) and one protein (RPP) subunit, however, the number of protein subunits is small.

The varieties of ribonuclease P.

Structure and Function of Bacterial RNase P

TLDR
RNase P is an endoribonuclease that cleaves tRNA precursors to generate the 5′-ends of mature tRNAs in prokaryotes and the reaction of the RNA with its substrates follows Michaelis-Menten kinetics.

Ribonuclease P as a snRNP

TLDR
In the absence of direct cloning of the gene for the RNA component and functional assays of the transcript of that cloned gene, it is possible to perform other biochemical tests to determine if the enzymatic activity has an essential RNA component.

Structural and functional similarities between MRP and RNase P

TLDR
RNase P, the enzyme responsible for 5′-end processing of tRNAs and 4.5S RNA, has been extensively characterized from E. coli and is the first true RNA enzyme to be characterized.

Ribozymes: catalytic RNAs that cut things, make things, and do odd and useful jobs.

Catalytic RNAs, or ribozymes, are a fossil record of the ancient molecular evolution of life on earth and still provide the essential core of macromolecule synthesis in all life forms today. Are they
...

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